X-研究院院长

张绪穆

X-研究院院长

生物医药研究院院长

讲席教授

zhangxm@sustech.edu.cn

教育经历：  

1992年  博士  斯坦福大学

1987年  硕士  加州大学圣地亚哥分校     

1985年  硕士  中国科学院福建物质结构研究所     

1982年  学士  武汉大学      

工作经历：    

2007-2015   讲席教授  新泽西州立大学

1994-2006   教授        美国宾夕法尼亚州州立大学       

1992-1994   博士后     斯坦福大学       

交叉研究领域：

（1）发展高效、高选择性不对称催化反应手性配体工具箱；

（2）发展高效、高选择性的化学催化反应（不对称氢化、不对称氢甲酰化、线性氢甲酰化、酯基以及酰胺类化合物的绿色还原等）；

（3）催化反应在重要的药物中间体和生物活性天然产物合成中的应用。

所获荣誉：

（1）Franklin Veatch Graduate Fellowship，Stanford University, 1991

（2）The Camille and Henry Dreyfus Foundation New Faculty Award, 1994

（3）DuPont Young Faculty Award, 1996

（4）Office of Naval Research Young Investigator Award, 1996

（5）The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998

（6）The John Simon Guggenheim Foundation Fellow, 2000

（7）The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000

（8）The Penn State Faculty Scholar Medal, 2001

（9）The American Chemical Society Arthur C. Cope Scholar Award, 2002

（10）The SDCA (San Diego Chinese Association) Achievement Award, 2002

（11）苏州工业园区第二届科技领军人才，2008

（12）“江苏省高层次创新创业人才引进计划”引进人才，2008

（13）姑苏创新创业领军人才，2009

（14）2010 年度“中国经济十大创新人物”，2011

代表文章：

（1）J. P. Collman*, X. Zhang, V. J. Lee, E. Uffelman, and J. I.Brauman; REGIOSELECTIVE AND ENANTIOSELECTIVE EPOXIDATION CATALYZED BY METALLOPORPHYRINS. Science, 1993, 261, 1404.

（2） J. P. Collman*, L. Fu, P. C. Herrmann, and X. Zhang; A Functional Model Related to Cytochrome C Oxidase and its Electrocatalytic Four-Electron Reduction of Dioxygen. Science, 1997, 275, 949.

（3）M. Gao, J. Meng, H. Lv, X. Zhang*; Highly Regio- and Enantioselective Synthesis of gamma-delta Unsaturated Amido Esters by Catalytic Hydrogenation of Conjugated Enamides. Angew. Chem. Int. Ed. 2015, 54, 1885.

（4） M. Chang, Y. Huang, S. Liu, Y. Chen, S. W. Krska, I. W. Davies, X. Zhang*; Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst. Angew. Chem. Int. Ed. 2014, 53, 12761.

（5）Q. Wang, W. Huang, H. Yuan, Q. Cai, L. Chen, H. Lv, X. Zhang*; Rhodium-Catalyzed Enantioseletive Hydrogenation of Tetrasubstituted α-Acetoxy β-Enamido Esters: a New Approach to Chiral α-Hydroxyl-β-Amino Acid derivatives. J. Am. Chem. Soc. 2014, 136, 16120.

（6） Q. Zhao, J. Wen, R. Tan, K. Huang, P. Metola, R. W, E. V. Anslyn, X. Zhang*; Rhodium-catalyzed asymmetric hydrogenation of unprotected NH imines assisted by a thiourea. Angew. Chem. Int. Ed. 2014, 53, 8467.

（7）T.-L. Liu, C.-J. Wang, X. Zhang*; Synthesis of Chiral Aliphatic Amines through Asymmetric Hydrogenation. Angew. Chem. Int. Ed.  2013, 52, 8416.

（8）S. Li, K. Huang, B. Cao, J. Zhang, W. Wu, X. Zhang*; Highly Enantioselective Hydrogenation of beta, beta-Disubstituted Nitroalkenes. Angew. Chem. Int. Ed. 2012, 51, 8573.

（9）M. Chang, W. Li, X. Zhang*; A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an iridium catalyst. Angew. Chem. Int. Ed, 2011, 50, 10679.

（10） G. Hou, W. Li, M. Ma, X. Zhang, X. Zhang*; Highly efficient Iridium-catalyzed asymmetric hydrogenation of unprotected β-Enamine esters. J. Am. Chem. Soc. 2010, 132, 12844.

（11）Hou, G., Tao, R., Sun, Y., Zhang, X.*, Gosselin, F.* Iridium-monodentate phosphoramidite-catalyzed asymmetric hydrogenation of substituted benzophenone N-H imines. J. Am. Chem. Soc., 2010, 132, 2124.

（12）Wang, D.-S., Chen, Q.-A., Li, W., Yu, C.-B., Zhou, Y.-G.*, Zhang, X.* Pd-catalyzed asymmetric hydrogenation of unprotected indoles activated by Bronsted acids. J. Am. Chem. Soc., 2010, 132, 8909.

（13）Zhang, X., Cao, B., Yu, S., Zhang, X.* Rhodium-catalyzed asymmetric hydroformylation of N-allylamides: highly enantioselective approach to beta2-amino aldehydes. Angew. Chem. Int. Ed., 2010, 49, 4047.

（14）Zhang, X., Huang, K., Hou, G., Cao, B., Zhang, X.* Electron-donating and rigid P-stereogenic bisphospholane ligands for highly enantioselective rhodium-catalyzed asymmetric hydrogenations. Angew. Chem. Int. Ed., 2010, 49, 6421.

（15）Zhang, W., Chi, Y., Zhang, X.* Developing chiral ligands for asymmetric hydrogenation. Acc. Chem. Res., 2007,  40, 1278.

（16）Tang, W; Zhang, X.*; New Chiral Phosphorus Ligands for Enantioselective Hydrogenation. Chem. Rev., 2003, 103, 3029.