生物医药研究院

方亮

生物医药研究院

研究副教授

fangl@sustech.edu.cn

教育经历

2013     柏林洪堡大学            细胞生物学博士

2007     浙江大学药学院     药理学硕士

2005     浙江大学               药学学士&生物技术学士

工作经历

2020－今 南方科技大学 前沿与交叉科学研究院 研究副教授

2017－2020 南方科技大学 生物系/前沿与交叉科学研究院 研究助理教授2013－2017  德国亥姆霍兹联合会马克斯-德尔布吕克分子医学中心博士后

2007－2008 德国柏林大学夏丽特医学院 研究助理

交叉研究领域

1. 肿瘤演化、肿瘤异质性、肿瘤上皮间质转化；

2. 基因转录后调控。

技术平台

1. CRISPR基因筛选；2. 单细胞测序；3. 类器官培养；4. 转基因小鼠。

代表文章

2021

Zhou, P., Y. Qi, X. Fang, M. Yang, S. Zheng, C. Liao, F. Qin, L. Liu, H. Li, Y. Li, E. Ravindran, C. Sun, X. Wei, W. Wang, L. Fang, D. Han, C. Peng, W. Chen, N. Li, A. M. Kaindl and H. Hu (2021). "Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m(6)A-methylation of Npdc1 and Cend1." iScience 24(6): 102645.

Long, Y., Z. Liu, J. Jia, W. Mo, L. Fang, D. Lu, B. Liu, H. Zhang, W. Chen and J. Zhai (2021). "FlsnRNA-seq: protoplasts-free full-length single-nucleus RNA profiling in plants." Genome Biol 22(1): 66.

Kamdem, N., Y. Roske, D. Kovalskyy, M. O. Platonov, O. Balinskyi, A. Kreuchwig, J. Saupe, L. Fang, A. Diehl, P. Schmieder, G. Krause, J. Rademann, U. Heinemann, W. Birchmeier and H. Oschkinat (2021). "Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling." Magn. Reson. 2(1): 355-374.

Fang, L.*#, G. Li#, Z. Sun, Q. Zhu, H. Cui, Y. Li, J. Zhang, W. Liang, W. Wei, Y. Hu and W. Chen* (2021). "CASB: a concanavalin A-based sample barcoding strategy for single-cell sequencing." Mol Syst Biol 17(4): e10060.

2020

Fang, L.*#, W. Wang#, G. Li#, L. Zhang, J. Li, D. Gan, J. Yang, Y. Tang, Z. Ding, M. Zhang, W. Zhang, D. Deng, Z. Song, Q. Zhu, H. Cui, Y. Hu and W. Chen* (2020). "CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators." Mol Syst Biol 16(11): e10025.

Yi, H.#, G. Li#, Y. Long, W. Liang, H. Cui, B. Zhang, Y. Tan, Y. Li, L. Shen, D. Deng, Y. Tang, C. Mao, S. Tian, Y. Cai, Q. Zhu, Y. Hu*, W. Chen* and L. Fang* (2020). "Integrative multi-omics analysis of a colon cancer cell line with heterogeneous Wnt activity revealed RUNX2 as an epigenetic regulator of EMT." Oncogene 39(28): 5152-5164.

Praktiknjo, S. D.*#, B. Obermayer#, Q. Zhu#, L. Fang, H. Liu, H. Quinn, M. Stoeckius, C. Kocks, W. Birchmeier* and N. Rajewsky* (2020). "Tracing tumorigenesis in a solid tumor model at single-cell resolution." Nat Commun 11(1): 991.

Wu, X., Y. Zheng, M. Liu, Y. Li, S. Ma, W. Tang, W. Yan, M. Cao, W. Zheng, L. Jiang, J. Wu, F. Han, Z. Qin, L. Fang, W. Hu, Z. Chen* and X. Zhang* (2020). "BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains." Autophagy: 1-13.

Li, Y.#, B. Schaefke*#, X. Zou, M. Zhang, F. Heyd, W. Sun, B. Zhang, G. Li, W. Liang, Y. He, J. Zhou, Y. Li, L. Fang, Y. Hu and W. Chen* (2020). "Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation." Mol Syst Biol 16(4): e9367.

Su, X., Y. Feng, S. A. Rahman, S. Wu, G. Li, F. Ruschendorf, L. Zhao, H. Cui, J. Liang, L. Fang, H. Hu, S. Froehler, Y. Yu, G. Patone, O. Hummel, Q. Chen, K. Raile, F. C. Luft, S. Bahring, K. Hussain, W. Chen, J. Zhang and M. Gong (2020). "Phosphatidylinositol 4-kinase beta mutations cause nonsyndromic sensorineural deafness and inner ear malformation." J Genet Genomics 47(10): 618-626.

2019

Zhu, Q.#, L. Fang#, J. Heuberger, A. Kranz, J. Schipper, K. Scheckenbach, R. O. Vidal, D. Y. Sunaga-Franze, M. Muller, A. Wulf-Goldenberg, S. Sauer and W. Birchmeier* (2019). "The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer." Cell Rep 26(2): 415-428 e415.

Wang, X., X. You, J. D. Langer, J. Hou, F. Rupprecht, I. Vlatkovic, C. Quedenau, G. Tushev, I. Epstein, B. Schaefke, W. Sun, L. Fang, G. Li, Y. Hu, E. M. Schuman and W. Chen* (2019). "Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus." Nat Commun 10(1): 5009.

Qi, X. T., Y. L. Li, Y. Q. Zhang, T. Xu, B. Lu, L. Fang, J. Q. Gao, L. S. Yu, D. F. Zhu, B. Yang, Q. J. He and M. D. Ying (2019). "KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells." Acta Pharmacol Sin 40(4): 546-555.

Lam, J. H., Y. Li, L. Zhu, R. Umarov, H. Jiang, A. Heliou, F. K. Sheong, T. Liu, Y. Long, Y. Li, L. Fang, R. B. Altman, W. Chen*, X. Huang* and X. Gao* (2019). "A deep learning framework to predict binding preference of RNA constituents on protein surface." Nat Commun 10(1): 4941.

Chen, T., B. Zhang, T. Ziegenhals, A. B. Prusty, S. Frohler, C. Grimm, Y. Hu, B. Schaefke, L. Fang, M. Zhang, N. Kraemer, A. M. Kaindl, U. Fischer* and W. Chen* (2019). "A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing." PLoS Genet 15(10): e1008460.

联系方式

fangl@sustech.edu.cn