生物医药研究院

陈根强

生物医药研究院

研究副教授

chengq@sustech.edu.cn

教育经历

2010.09-2015.07 中国科学院上海有机化学研究所, 有机化学, 博士学位, 导师：施敏

2006.09-2010.07 郑州大学化学系, 学士学位，导师：陶京朝

工作经历

2021.06-present 南方科技大学前沿与交叉科学研究院，研究副教授

2018.07-2021.05 南方科技大学前沿与交叉科学研究院，研究助理教授

2016.01-2018.06 南方科技大学化学系, 博士后(校长卓越博士后), 导师: 张绪穆

2015.07-2015.10 康龙化成(宁波), 高级研究员.

交叉研究领域

1. 新型手性配体的设计、合成及其在不对称催化领域的应用

2. 天然产物以及药物分子的高效不对称合成

3. 挑战性底物的不对称氢化和不对称转移氢化

代表文章

1. G.-Q. Chen, B.-J. Lin, J.-M. Huang, L.-Y. Zhao, Q.-S. Chen, S.-P. Jia, Q. Yin,* X. Zhang* Design and synthesis of chiral oxa-spirocyclic ligands for Ir-catalyzed direct asymmetric reduction of Bringmann’s lactones with molecular H₂. J. Am. Chem. Soc., 2018, 140, 8064-8068;

2. Chen, G.-Q.*; Huang, J.-M.; Lin, B.-J.; Shi, C.; Zhao, L.-Y.; Ma, B.-D.; Ding, X.-B.; Yin, Q.; Zhang, X.* Highly Enantioselective Hydrogenation of tetra- and tri-Substituted α,β-Unsaturated Carboxylic Acids with oxa-Spiro Diphosphine Ligands. CCS Chem. 2020, 2, 468-477;

3. Du, X.^#; Xiao, Y.^#; Huang, J.-M.; Zhang, Y.; Duan, Y.-N.; Wang, H.; Shi, C.; Chen, G.-Q.*; Zhang X.* Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids. Nat. Commun. 2020, 11, 3239;

4. Du X.^#; Xiao, Y.^#; Yang, Y.^#; Duan, Y.-N.; Li, F.; Hu, Q.; Chung, L. W.*; Chen, G.-Q.*; Zhang, X.*, Enantioselective Hydrogenation of tetra-Substituted α,β-Unsaturated Carboxylic Acids Enabled by Cobalt(II) Catalysis: Scope and Mechanistic Insights, Angew. Chem., Int. Ed. 2021, DOI: 10.1002/anie.202016705;

5. Wang, F.; Yang, T.; Wu, T.; Zheng, L. S.; Yin, C.; Shi, Y.; Ye, X. Y.; Chen, G. Q.*; Zhang, X.*, Asymmetric Transfer Hydrogenation of α-Substituted-β-Keto Carbonitriles via Dynamic Kinetic Resolution, J. Am. Chem. Soc. 2021, 143, 2477-2483;

6. Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.*; Lu, Y.; Zhang, X.* Concise, scalable and enantioselective total synthesis of prostaglandins, Nat. Chem. 2021, in press;

7. Ye, X.-Y.; Liang, Z.-Q.; Jin, C.; Lang, Q.-W.; Chen, G.-Q.*; Zhang, X.*, Design of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin via iridium-catalyzed asymmetric hydrogenation, Chem. Commun. 2021, 57, 195-198;

8. Zheng, L.-S.; Wang, F.; Ye, X.-Y.; Chen, G.-Q.*; Zhang, X.*, Asymmetric Hydrogenation of 2-Aryl-3-phthalimidopyridinium Salts: Synthesis of Piperidine Derivatives with Two Contiguous Stereocenters, Org. Lett. 2020, 22, 8882-8887;

9. Zeng, W.; Tan, X.; Yu, Y.; Chen, G.-Q.*; Zhang, X.*, Copper-Catalyzed Asymmetric Hydrosilylation of beta-Nitroethyl Aryl Ketones, Org. Lett. 2020, 22, 858-862; 

10. Wang, F.; Tan, X.; Wu, T.; Zheng, L.-S.; Chen, G.-Q.*; Zhang, X.*, Ni-Catalyzed asymmetric reduction of alpha-keto-beta-lactams via DKR enabled by proton shuttling, Chem. Commun. 2020, 56, 15557-15560;

11. Chen, G.-Q.; Zhang, X.-N.; Wei, Y.; Tang, X.-Y.*; Shi, M.* Catalyst Dependent Divergent Synthesis of Pyrroles from 3-Alkynyl Imine Derivatives: Non-carbonylative and Carbonylative Approach. Angew. Chem. Int. Ed. 2014, 53, 8492-8497;

12. Divergent reaction pathways in gold-catalyzed cycloisomerization of 1,5-enynes containing a cyclopropane ring: dramatic ortho substituent and temperature effects. Chen, G.-Q.; Fang, Wei; Wei, Yin; Tang, X.-Y.*; Shi, M.* Chem. Sci., 2016, 7, 4318-4328.

13. Gold catalyzed dehydrogenative cycloisomerization of 1,5-enynes. Chen, G.-Q.; Fang, Wei; Wei, Yin; Tang, X.-Y.*; Shi, M.* Chem. Commun., 2016, 52, 10799-10802;

14. Chen, G.-Q.; Shi, M.* Rhodium-catalyzed Tandem Pauson-Khand Type Reactions of 1,4 Enynes Tethered by a Cyclopropyl Group. Chem. Commun. 2013, 49, 698-700;

15. Chen, G.-Q.; Tang, X.-Y.; Shi, M.* HOTf Mediated Cascade Reactions of 1-Arenoylcyclopropanecarboxylic Acids with Arenes. Chem. Commun. 2012, 48, 2340-2342.

联系方式

chengq@sustech.edu.cn

0755-88018340